Clozapine may not be all it's been cracked up to be
A recent meta-analysis of antipsychotic drug treatment for people with ‘treatment refractory schizophrenia’ suggests clozapine may not be better than other antipsychotics. Clozapine has been the mainstay of treatment for this group since a landmark study by American psychiatrist, John Kane, in 1988 found it to be substantially superior to the old antipsychotic chlorpromazine. Subsequent studies have found much smaller differences between clozapine and other antipsychotic drugs, however.